Ultrastructure of early lipid accumulation in ApoE-deficient mice.

  title={Ultrastructure of early lipid accumulation in ApoE-deficient mice.},
  author={Minna Tamminen and Giuseppe Mottino and Jian-hua Qiao and Jan L. Breslow and Joy S. Frank},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={19 4},
Apolipoprotein (apo) E-deficient mice develop severe hypercholesterolemia and have lesions that progress from fatty streaks to fibrous plaques distributed in lesion-prone areas throughout the aorta. Lesions develop in apoE-deficient mice on a regular chow diet and will occur faster on a diet higher in cholesterol. Examination of the aortas from these mice on a chow diet by high-resolution, freeze-etch electron microscopy demonstrated lipid retention in the intima by 3 weeks of age. Lipid was… CONTINUE READING


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