Ultrastructure of amyloid fibrils in Alzheimer's disease and Down's syndrome.

@article{Miyakawa1986UltrastructureOA,
  title={Ultrastructure of amyloid fibrils in Alzheimer's disease and Down's syndrome.},
  author={Taihei Miyakawa and Kazuyoshi Watanabe and Shoichi Katsuragi},
  journal={Virchows Archiv. B, Cell pathology including molecular pathology},
  year={1986},
  volume={52 2},
  pages={99-106}
}
Amyloid fibrils in brains of patients with Alzheimer's disease and Down's syndrome were examined by light and electron microscopy. In addition, replicas of amyloid fibrils produced by a quick freezing method from the brain of a patient with Down's syndrome were examined by electron microscopy. The amyloid fibrils were shown to consist of hollow rods. These were composed of filaments arranged as a tightly coiled helix, each turn of which consisted of five globular subunits. This structure… CONTINUE READING