Ultrastructure and phylogenetic analysis of 'Candidatus Neoehrlichia mikurensis' in the family Anaplasmataceae, isolated from wild rats and found in Ixodes ovatus ticks.

@article{Kawahara2004UltrastructureAP,
  title={Ultrastructure and phylogenetic analysis of 'Candidatus Neoehrlichia mikurensis' in the family Anaplasmataceae, isolated from wild rats and found in Ixodes ovatus ticks.},
  author={Makoto Kawahara and Yasuko Rikihisa and Emiko Isogai and Mamoru Takahashi and Hitoko Misumi and Chiharu Suto and Shinichiro Shibata and Chunbin Zhang and Masayoshi Tsuji},
  journal={International journal of systematic and evolutionary microbiology},
  year={2004},
  volume={54 Pt 5},
  pages={1837-43}
}
A novel bacterium that infects laboratory rats was isolated from wild Rattus norvegicus rats in Japan. Transmission electron microscopy of the spleen tissue revealed small cocci surrounded by an inner membrane and a thin, rippled outer membrane in a membrane-bound inclusion within the cytoplasm of endothelial cells. Phylogenetic analysis of the 16S rRNA gene sequence of the bacterium found in R. norvegicus rats and Ixodes ovatus ticks in Japan revealed that the organism represents a novel clade… CONTINUE READING
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