Ultrastructure and immunoreactivity of dystrophic axons indicate a different pathogenesis of Hallervorden-Spatz disease and infantile neuroaxonal dystrophy

@article{Malandrini1995UltrastructureAI,
  title={Ultrastructure and immunoreactivity of dystrophic axons indicate a different pathogenesis of Hallervorden-Spatz disease and infantile neuroaxonal dystrophy},
  author={Alessandro Malandrini and Tiziana L Cavallaro and Gian Maria Fabrizi and Gianna Berti and R. Salvestroni and Claudio Salvadori and Gian Carlo Guazzi},
  journal={Virchows Archiv},
  year={1995},
  volume={427},
  pages={415-421}
}
An immunohistochemical and ultrastructural analysis of dystrophic axons (DAs) in the brain and peripheral nerve of a patient with familial infantile neuroaxonal dystrophy (INAD) and in the brain of a patient with familial Hallervorden-Spatz Disease (HSD) revealed prevalent membrano-tubular or granulo-vesicular profiles with a graded pattern of evolution in INAD, while dense bodies, vesicles and amorphous material were pressent in HSD. DAs immunoreactivity with τ-protein and 200 kDa… CONTINUE READING