Ultrastructure and biochemical composition of paired helical filaments in corticobasal degeneration.

@article{KsiakReding1994UltrastructureAB,
  title={Ultrastructure and biochemical composition of paired helical filaments in corticobasal degeneration.},
  author={Hanna Księżak-Reding and Kelly B. Morgan and Linda A Mattiace and Peter Davies and Wei Liu and S. H. Yen and Karen M. Weidenheim and Dennis W. Dickson},
  journal={The American journal of pathology},
  year={1994},
  volume={145 6},
  pages={1496-508}
}
Corticobasal degeneration (CBD) is a neurodegenerative disorder associated with extensive cytoskeletal abnormalities. These include tau-positive neuropil threads and grains, ballooned or swollen neurons, neurofibrillary tangles, and glial inclusions. Given the presence of tau-positive structures in CBD, we investigated whether abnormalities in tau proteins associated with CBD were similar to those in Alzheimer's disease (AD). Fractions of abnormal tau proteins were isolated as Sarkosyl… CONTINUE READING
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