Ultrastructural studies on the pathogenesis of poliomyelitis in monkeys infected with polivirus

@article{Hashimoto1984UltrastructuralSO,
  title={Ultrastructural studies on the pathogenesis of poliomyelitis in monkeys infected with polivirus},
  author={Isao Hashimoto and Akio Hagiwara and Takaaki Komatsu},
  journal={Acta Neuropathologica},
  year={1984},
  volume={64},
  pages={53-60}
}
Poliovirus was inoculated intraspinally into cynomolgus monkeys to determine whether nerve cell damage in the central nervous system (CNS) is due primarily to virus multiplication in the neuron or to secondary effects of virus multiplication in the supporting cells. Electron-microscopically, the development of cytopathogenesis and of membrane-bound vesicles and virus particles in the neurons of the CNS in monkeys infected with poliovirus was compared with that of infected cultured cynomolgus… CONTINUE READING