Ultrastructural studies of the blood-retina barrier after exposure to interleukin-1 beta or tumor necrosis factor-alpha.

@article{Claudio1994UltrastructuralSO,
  title={Ultrastructural studies of the blood-retina barrier after exposure to interleukin-1 beta or tumor necrosis factor-alpha.},
  author={Luz Claudio and James A. Martiney and Celia F. Brosnan},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1994},
  volume={70 6},
  pages={850-61}
}
BACKGROUND During inflammatory conditions of the central nervous system (CNS), the protective function of the blood-brain barrier (BBB) may be compromised, resulting in CNS edema. However, it is not well understood how inflammatory cells may increase BBB permeability, since increased transendothelial transport of serum proteins is observed in CNS capillaries that are not directly in contact with inflammatory cells. One possible explanation may be that soluble inflammatory factors may cause BBB… CONTINUE READING

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Once the permeability of the BRB endothelium is increased , perivascular phagocytic cells such as perivascular , microglia and Müller cells may act as secondary barriers to extravasated proteins .
During inflammatory conditions of the central nervous system ( CNS ) , the protective function of the blood - brain barrier ( BBB ) may be compromised , resulting in CNS edema .
During inflammatory conditions of the central nervous system ( CNS ) , the protective function of the blood - brain barrier ( BBB ) may be compromised , resulting in CNS edema .
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