Ultrastructural remodelling of Ca(2+) signalling apparatus in failing heart cells.

@article{Wu2012UltrastructuralRO,
  title={Ultrastructural remodelling of Ca(2+) signalling apparatus in failing heart cells.},
  author={Hao-Di Wu and Ming Xu and Rong-Chang Li and Liang Guo and Ying-Si Lai and Shi-Ming Xu and Su-Fang Li and Quan-Long L{\"u} and Lin-lin Li and Haibo Zhang and Y Jonathan Zhang and C Zhang and Shi-Qiang Wang},
  journal={Cardiovascular research},
  year={2012},
  volume={95 4},
  pages={430-8}
}
AIMS The contraction of a heart cell is controlled by Ca(2+)-induced Ca(2+) release between L-type Ca(2+) channels (LCCs) in the cell membrane/T-tubules (TTs) and ryanodine receptors (RyRs) in the junctional sarcoplasmic reticulum (SR). During heart failure, LCC-RyR signalling becomes defective. The purpose of the present study was to reveal the ultrastructural mechanism underlying the defective LCC-RyR signalling and contractility. METHODS AND RESULTS In rat models of heart failure produced… CONTINUE READING