Dendritic cells in atherosclerotic inflammation: the complexity of functions and the peculiarities of pathophysiological effects
The present study was undertaken to determine whether dendritic cells contributed to the intimal abnormalities seen in the aortas of chickens infected with Marek's disease. Semithin sections were used to select aortic segments in which the intima was thickened by lymphocytic infiltrates. Ultrathin sections were then examined. Intermingled with lymphocytes within the intimal thickenings were cells with an appearance typical of dendritic cells including long processes and a unique tubulovesicular system. In these cellular processes the tubulovesicular system was hypertrophied with the tubular cisterns characteristically forming concentric cyclical layers. Our observations show that dendritic cells are present in the aortic lesions of Marek's disease and are presumably involved in related immune mechanisms.