Ultrastructural observations on the effect of 4-hydroxyanisole on normal human melanocytes in tissue culture.

@article{Breathnach1981UltrastructuralOO,
  title={Ultrastructural observations on the effect of 4-hydroxyanisole on normal human melanocytes in tissue culture.},
  author={Aodh{\'a}n S Breathnach and E B Diala and Susan M Gallagher and Marcella Nazzaro Porro and Siro Passi},
  journal={The Journal of investigative dermatology},
  year={1981},
  volume={77 3},
  pages={292-6}
}
Riley's classic 1970 experiment showing a specific cytotoxic effect of 4-hydroxyanisole (4-OHA) on tissue-cultured melanocytes of black guinea pig ear skin was repeated on normal human melanocytes, and the results were examined by electron microscopy. In dispersed tissue culture, no specific toxic effect on human melanocytes was observed following equally timed exposures to similar (10(-3) M) or even higher (10(-2) M) concentrations of the drug; plasma membrane, nucleus, and cytoplasmic… CONTINUE READING

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In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
melanocyteAnatomic structure is physical part ofEpidermis
The same applied to melanocytes of whole epidermis exposed for 5 hr to the same concentrations of 4-OHA in culture medium .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
In dispersed tissue culture , no specific toxic effect on human melanocytes was observed following equally timed exposures to similar ( 10(-3 ) M ) or even higher ( 10(-2 ) M ) concentrations of the drug ; plasma membrane , nucleus , and cytoplasmic organelles , including melanosomes were unaffected .
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