Ultrastructural modifications of proteoglycans coincident with mineralization in local regions of rat growth plate.

@article{Shepard1985UltrastructuralMO,
  title={Ultrastructural modifications of proteoglycans coincident with mineralization in local regions of rat growth plate.},
  author={N L Shepard and Nell Mitchell},
  journal={The Journal of bone and joint surgery. American volume},
  year={1985},
  volume={67 3},
  pages={455-64}
}
We carried out histochemical and electron-microscopic studies to examine the relationship between mineral deposition and changes in the organization of proteoglycans during mineralization in the cartilaginous growth plate of the rat. To preserve the distribution and organization of proteoglycans in the extracellular matrix and to stain proteoglycans, acridine orange was included in the solutions that were used for fixation and demineralization. In undecalcified sections, mineral crystals that… CONTINUE READING
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