Ultrastructural modifications in tissues of a “late” cortical post-traumatic epileptic nidus in rabbits

Abstract

Using electron microscopy, we studied the sensorimotor cortex tissues in rabbits with a “late” post-traumatic cortical epileptic nidus (one year after craniocerebral trauma). In such nidus, we observed destructive and plastic modifications of the neuron-glia-capillary morphofunctional system; these were hyperplasia of the endothelium, thickening of the basal membrane of capillaries, and hyperplasia of glia. In a part of the neurons, manifestations of a hypoxic state and partial deafferentation were obvious, but in most cells manifestations of increased functional and metabolic activity (activation of the axo-dendritic connections, plastic and conformational modifications of the synaptic membranes and paramembrane complexes, and increased level of energy supply of the synaptic processes) dominated. The means of the width of synaptic clefts and such morphometric coefficients, as length of the active zonevs length of the synaptic contact and thickness of post-synapticvs thickness of pre-synaptic thickenings, significantly exceeded the control indices.

DOI: 10.1007/BF02515116

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Cite this paper

@article{Cherchenko2006UltrastructuralMI, title={Ultrastructural modifications in tissues of a “late” cortical post-traumatic epileptic nidus in rabbits}, author={A. P. Cherchenko}, journal={Neurophysiology}, year={2006}, volume={31}, pages={336-340} }