Ultrastructural localization of delta-opioid receptor and Met5-enkephalin immunoreactivity in rat insular cortex.

@article{Svingos1995UltrastructuralLO,
  title={Ultrastructural localization of delta-opioid receptor and Met5-enkephalin immunoreactivity in rat insular cortex.},
  author={Adena L Svingos and Ping-chin Cheng and Carol L Clarke and Virginia M Pickel},
  journal={Brain research},
  year={1995},
  volume={700 1-2},
  pages={25-39}
}
The insular cortex has been implicated in the reinforcing properties of opiates as well as in the integration of responses to sensory-motor stimulation. Moreover, the delta-opioid receptor (DOR) and the endogenous opioid ligand, Met5-enkephalin (ENK) are known to be prominently distributed in insular limbic cortex. To examine the anatomical sites for opioid activation of DOR in rat insular cortex, we used immunoperoxidase for detection of an antiserum raised against a peptide sequence unique to… CONTINUE READING
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