Ultrastructural localization of choline acetyltransferase in vascular endothelial cells in rat brain

@article{Parnavelas1985UltrastructuralLO,
  title={Ultrastructural localization of choline acetyltransferase in vascular endothelial cells in rat brain},
  author={John G. Parnavelas and William H Kelly and Geoffrey Burnstock},
  journal={Nature},
  year={1985},
  volume={316},
  pages={724-725}
}
Furchgott and Zawadski1 have shown that acetylcholine (ACh) does not act directly on the smooth muscle of blood vessel walls, but rather via receptors on the endothelial cells lining the lumen, to release an endothelium-derived relaxing factor (EDRF). As it is very unlikely that neurotransmitter released from the periarterial nerves, which are confined to the adventitial–medial border, diffuses all the way through the medial muscle coat before acting on endothelial cells to release EDRF to… CONTINUE READING
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