Ultrastructural investigation of crystal deposits in Npt2a knockout mice: are they similar to human Randall's plaques?

PURPOSE Idiopathic Ca oxalate stones may develop with attachment to renal interstitial Ca phosphate deposits (Randall's plaques). Sodium phosphate cotransporter (Npt2a) null mice have hypercalciuria and hyperphosphaturia, and produce tubular and interstitial Ca phosphate deposits. To determine whether this mouse is suitable for Randall's plaque… CONTINUE READING