Ultrastructural immunolocalization of basic fibroblast growth factor in mast cell secretory granules. Morphological evidence for bfgf release through degranulation.

@article{Qu1998UltrastructuralIO,
  title={Ultrastructural immunolocalization of basic fibroblast growth factor in mast cell secretory granules. Morphological evidence for bfgf release through degranulation.},
  author={Z Qu and Robert J. Kayton and Peyman Ahmadi and Janice M Liebler and Michael R Powers and Stephen R. Planck and James T. Rosenbaum},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1998},
  volume={46 10},
  pages={1119-28}
}
We previously reported that mast cells (MCs) serve as a source of basic fibroblast growth factor (bFGF), a potent angiogenic and mitogenic polypeptide, suggesting that bFGF may mediate MC-related neovascularization and fibroproliferation. Unlike many other growth factors, bFGF lacks a classic peptide sequence for its secretion, and the mechanism(s) for its release remains controversial. Because MCs release a wide spectrum of bioactive products via degranulation, we hypothesized that MC… CONTINUE READING

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