Ultrastructural immuno-localization of synthetic prion protein peptide antibodies in 87V murine scrapie.

@article{Jeffrey1996UltrastructuralIO,
  title={Ultrastructural immuno-localization of synthetic prion protein peptide antibodies in 87V murine scrapie.},
  author={M Haddad Jeffrey and Caroline M. Goodsir and Nina Fowler and James Hope and Moira E. Bruce and Patricia A. McBride},
  journal={Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration},
  year={1996},
  volume={5 1},
  pages={101-9}
}
Disease specific forms of a host encoded cell surface sialoglycoprotein called prion protein (PrP) accumulate during this incubation period of the transmissible spongiform encephalopathies. A 33-35 kDa disease specific form of PrP is partially resistant to protease digestion whereas the normal form of PrP can be completely digested. Proteinase K digestion of the murine disease specific form of PrP produces diverse forms of low molecular weight PrP, some of which are N-terminally truncated at… CONTINUE READING

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