Ultrastructural histopathology in a case of human ototoxicity due to loop diuretics.

@article{Arnold1981UltrastructuralHI,
  title={Ultrastructural histopathology in a case of human ototoxicity due to loop diuretics.},
  author={Wolfgang Arnold and Joseph B. Nadol and Hagen Weidauer},
  journal={Acta oto-laryngologica},
  year={1981},
  volume={91 5-6},
  pages={399-414}
}
The temporal bones of a patient who suffered sudden deafness and ataxia after administration of both furosemide and ethacrynic acid, were prepared for light and electron microscopy. There was no loss of hair or supporting cells. However, some hair cells, in both the vestibular neuroepithelium and the organ of Corti, particularly in the basal turn, were more densely staining and more granular than normal. Membrane whorls also were common within mitochondria of such cells. The endoplasmic… CONTINUE READING

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