Ultrastructural features on the platelet response to phorbol myristate acetate.

@article{Estensen1974UltrastructuralFO,
  title={Ultrastructural features on the platelet response to phorbol myristate acetate.},
  author={Richard D. Estensen and James Gardiner White},
  journal={The American journal of pathology},
  year={1974},
  volume={74 3},
  pages={
          441-52
        }
}
Phorbol myristate acetate (PMA) the active ingredient of croton oil, is a potent stimulus of irreversible platelet aggregation. The present study has examined the effects of PMA on platelet fine structure during aggregation and after incubation. PMA appears to act primarily on channels of the open canalicular system and intracellular granules. Small amounts of the agent cause dilatation of some open channels and conversion of granules to swollen vacuoles. Platelet discoid shape is not affected… CONTINUE READING

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