Ultrastructural evidence that insoluble microtubules are components of the neurofibrillary tangle

@article{Pappolla1990UltrastructuralET,
  title={Ultrastructural evidence that insoluble microtubules are components of the neurofibrillary tangle},
  author={Miguel A. Pappolla and Julia Alzofon and J T. Mcmahon and Theodor J. Theodoropoulos},
  journal={European archives of psychiatry and neurological sciences},
  year={1990},
  volume={239},
  pages={314-319}
}
The ultrastructure of Alzheimer's neurofibrillary tangles is heterogeneous and includes abnormal paired helical filaments (PHF) and various other insoluble structures. Insoluble non-PHF components isolated from neurofibrillary tangles were examined by electron microscopy. Comparison of these fractions with normal assembled neurofilaments and normal brain microtubules revealed scattered profiles which were morphologically (not chemically) identical to structures present in the microtubule, but… CONTINUE READING
4 Extracted Citations
36 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 36 references

Deciphering Alzheimer's disease: the pace quickens

  • DJ Selkoe
  • Trends Neurosci
  • 1987
2 Excerpts

Similar Papers

Loading similar papers…