Ultrastructural evidence of piecemeal degranulation in large dense-core vesicles of brain neurons

  title={Ultrastructural evidence of piecemeal degranulation in large dense-core vesicles of brain neurons},
  author={Enrico Crivellato and B Nico and Domenico Ribatti},
  journal={Anatomy and Embryology},
Large dense-core vesicles (LDCV) are a group of neuronal secretory organelles with different size and characteristically condensed morphology. LDCV release their specific cargo by regulated exocytosis, either in the form of “full fusion” or “kiss-and-run” exocytosis. In this paper, we provide ultrastructural evidence indicative of a slow and particulate mode of secretion from LDCV, called piecemeal degranulation (PMD). A number of LDCV in the nerve boutons of mouse brain presented marked… CONTINUE READING


Publications citing this paper.
Showing 1-7 of 7 extracted citations

Ultrastructure of synapses in the mammalian brain.

Cold Spring Harbor perspectives in biology • 2012
View 2 Excerpts

Exocytosis of norepinephrine at axon varicosities and neuronal cell bodies in the rat brain.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2007


Publications referenced by this paper.
Showing 1-10 of 42 references

Secretory granule exocytosis.

Physiological reviews • 2003
View 16 Excerpts
Highly Influenced

Secretion: Kiss and Run Caught on Film

Current Biology • 2003
View 4 Excerpts
Highly Influenced

Membrane trafficking in nerve terminals.

Advances in pharmacology • 1995
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…