Ultrastructural evidence of piecemeal degranulation in large dense-core vesicles of brain neurons

@article{Crivellato2005UltrastructuralEO,
  title={Ultrastructural evidence of piecemeal degranulation in large dense-core vesicles of brain neurons},
  author={Enrico Crivellato and B Nico and Domenico Ribatti},
  journal={Anatomy and Embryology},
  year={2005},
  volume={210},
  pages={25-34}
}
Large dense-core vesicles (LDCV) are a group of neuronal secretory organelles with different size and characteristically condensed morphology. LDCV release their specific cargo by regulated exocytosis, either in the form of “full fusion” or “kiss-and-run” exocytosis. In this paper, we provide ultrastructural evidence indicative of a slow and particulate mode of secretion from LDCV, called piecemeal degranulation (PMD). A number of LDCV in the nerve boutons of mouse brain presented marked… CONTINUE READING

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