Ultrastructural evidence for intracellular formation of amyloid fibrils in macrophages

  title={Ultrastructural evidence for intracellular formation of amyloid fibrils in macrophages},
  author={Mutsuo Takahashi and Tadaaki Yokota and Hiroo Kawano and Toshikazu Gondo and Tokuhiro Ishihara and Fumiya Uchino},
  journal={Virchows Archiv A},
Early amyloid deposition in the spleen was studied by immunoelectron microscopy following the administration of rapid amyloid-inducing agents to mice. Two days after the injection of an amyloidenhancing factor and casein solution, a small amount of amyloid material was observed at the border of the white pulp and the marginal zone (perifollicular area) and also within the white pulp. At this stage, amyloid fibrils were seen mainly in an extracellular distribution along the cytoplasmic processes… CONTINUE READING


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