Ultrastructural development of hyperosteoidosis in 1,25(OH)2D3-treated rats fed high levels of dietary calcium.

@article{Boyce1985UltrastructuralDO,
  title={Ultrastructural development of hyperosteoidosis in 1,25(OH)2D3-treated rats fed high levels of dietary calcium.},
  author={Rogely Waite Boyce and Steven E. Weisbrode and O R Kindig},
  journal={Bone},
  year={1985},
  volume={6 3},
  pages={
          165-72
        }
}
View on PubMed
doi.org
14 Citations

14 Citations

Citation Type

Citation Type

Histogenesis of hyperosteoidosis in 1,25(OH)2D3-treated rats fed high levels of dietary calcium.
Skeletal resistance to 1,25-dihydroxyvitamin D3 in osteopetrotic rats
TLDR
High dose calcitriol therapy, under the conditions and period of treatment used in this study, failed to stimulate bone turnover in op rats, suggesting that they are resistant to the skeletal effects of 1,25(OH)2D3.
The effects of the major vitamin D metabolites upon the resolution of osteomalacia in uremic adult rats.
Short-term treatment of rats with high dose 1,25-dihydroxyvitamin D3 stimulates bone formation and increases the number of osteoblast precursor cells in bone marrow.
TLDR
Evidence is provided that short-term 1,25-(OH)2D3 treatment creates new bone remodeling units and augments osteoblast recruitment and osteoblastic team performance in rat cancellous bone.
The effects of uremia and dietary phosphorus on the bone of rats.
The effect of dietary vitamin D metabolites and zinc on normal and ectopic bone formation in weanling rats
Calcium and vitamin D enriched diets increase and preserve vertebral mineral content in aging laboratory rats.
The ultrastructural effects of parathyroid-hormone, calcitonin, and vitamin D on bone
TLDR
The objectives of this chapter are to review the effects of parathyroid hormone, calcitonin, and vitamin D on the ultrastructure of bone.
Hypophosphatemic rickets with hypocalciuria following long-term treatment with aluminum-containing antacid.
Hormonal Effects on Bone, Rat
TLDR
The morphologic expressions of calcium homeostasis are defined here as structural variations seen in bone cells, bone fluid, and bone mineral and matrix in response to agents which affect serum calcium.
...
1
2
...

References

SHOWING 1-10 OF 15 REFERENCES
Histogenesis of hyperosteoidosis in 1,25(OH)2D3-treated rats fed high levels of dietary calcium.
Ultrastructural evaluation of the effects of 1,25-dihydroxyvitamin D3 on bone of thyroparathyroidectomized rats fed a low-calcium diet.
TLDR
It is concluded that 1,25-(OH)2D3 is able to significantly elevate serum calcium independent of dietary calcium, parathyroid hormone, and calcitonin primarily by increasing ostoeclasis with minimal dependence on osteocytic osteolysis.
Effect of dietary calcium on the response of bone to 1,25 (OH)2D3.
TLDR
Only diets containing adequate dietary calcium permit exogenous pharmacologic levels of 1,25(OH)2D3 to produce a positive skeletal balance either by decreasing osteoclasis and/or increasing bone matrix synthesis.
Light- and electron-microscopic evaluation of the effects of 1,25-dihydroxyvitamin D3 on bone of thyroparathyroidectomized rats.
TLDR
It is concluded that in metaphyseal bone 1,25-(OH)2D3 increased the number and synthetic activity of osteoblasts without significantly enhancing osteoclasis or osteocytic osteolysis in rats fed a normal rodent diet.
Solanum malacoxylon toxicity: inhibition of bone resorption.
TLDR
It was concluded that the recommended dietary calcium for growing rabbits--about 0.6%--is too high and bones from rabbits on high calcium showed retarded resorption and the rabbits had a relative hypophosphatasemia.
Vitamin D and Cartilage. II. Biological Activity of 25-Hydroxycholecalciferol and 24,25- and 1,25-Dihydroxycholecalciferols on Cultured Growth Plate Chondrocytes*
In order to study the effect of vitamin D3, and some of its metabolites on cartilage, chondrocytes from the proliferative zone of rabbit growth plate cartilage were isolated and grown in culture. The…
Osteoclast formation in response to intraperitoneal injection of 1 alpha-hydroxycholecalciferol in mice.
TLDR
Although the osteoclast population was most dense at the metaphyseal plate in both experimental and control groups, osteOClast counts in this region only doubled whereas overall osteoc last counts more than tripled.
Hormonal control of bone collagen synthesis in vitro: inhibitory effect of 1-hydroxylated vitamin D metabolites.
The effects of vitamin D metabolites on bone collagen synthesis were assessed in organ cultures of fetal rat calvaria by measuring the incorporation of a 2-h pulse of [3H]proline into…
Alterations of the gamma-carboxyglutamic acid and osteocalcin concentrations in vitamin D-deficient chick bone.
1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture
TLDR
1,25-Dihydroxycholecalciferol stimulated the release of previously incorporated 4545Ca from fetal rat bones in organ culture, at concentrations of 10-10 to 10-8M, suggesting brief exposure to maximum doses of either agent leads to prolonged bone resorption.
...
1
2
...