Ultrastructural development of hyperosteoidosis in 1,25(OH)2D3-treated rats fed high levels of dietary calcium.

@article{Boyce1985UltrastructuralDO,
  title={Ultrastructural development of hyperosteoidosis in 1,25(OH)2D3-treated rats fed high levels of dietary calcium.},
  author={Rogely Waite Boyce and Steven E. Weisbrode and O R Kindig},
  journal={Bone},
  year={1985},
  volume={6 3},
  pages={
          165-72
        }
}
14 Citations
Skeletal resistance to 1,25-dihydroxyvitamin D3 in osteopetrotic rats
TLDR
High dose calcitriol therapy, under the conditions and period of treatment used in this study, failed to stimulate bone turnover in op rats, suggesting that they are resistant to the skeletal effects of 1,25(OH)2D3.
Short-term treatment of rats with high dose 1,25-dihydroxyvitamin D3 stimulates bone formation and increases the number of osteoblast precursor cells in bone marrow.
TLDR
Evidence is provided that short-term 1,25-(OH)2D3 treatment creates new bone remodeling units and augments osteoblast recruitment and osteoblastic team performance in rat cancellous bone.
The ultrastructural effects of parathyroid-hormone, calcitonin, and vitamin D on bone
TLDR
The objectives of this chapter are to review the effects of parathyroid hormone, calcitonin, and vitamin D on the ultrastructure of bone.
Hormonal Effects on Bone, Rat
TLDR
The morphologic expressions of calcium homeostasis are defined here as structural variations seen in bone cells, bone fluid, and bone mineral and matrix in response to agents which affect serum calcium.
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TLDR
It is concluded that 1,25-(OH)2D3 is able to significantly elevate serum calcium independent of dietary calcium, parathyroid hormone, and calcitonin primarily by increasing ostoeclasis with minimal dependence on osteocytic osteolysis.
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TLDR
Only diets containing adequate dietary calcium permit exogenous pharmacologic levels of 1,25(OH)2D3 to produce a positive skeletal balance either by decreasing osteoclasis and/or increasing bone matrix synthesis.
Light- and electron-microscopic evaluation of the effects of 1,25-dihydroxyvitamin D3 on bone of thyroparathyroidectomized rats.
TLDR
It is concluded that in metaphyseal bone 1,25-(OH)2D3 increased the number and synthetic activity of osteoblasts without significantly enhancing osteoclasis or osteocytic osteolysis in rats fed a normal rodent diet.
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It was concluded that the recommended dietary calcium for growing rabbits--about 0.6%--is too high and bones from rabbits on high calcium showed retarded resorption and the rabbits had a relative hypophosphatasemia.
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TLDR
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1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture
TLDR
1,25-Dihydroxycholecalciferol stimulated the release of previously incorporated 4545Ca from fetal rat bones in organ culture, at concentrations of 10-10 to 10-8M, suggesting brief exposure to maximum doses of either agent leads to prolonged bone resorption.
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