Ultrastructural characteristics of therapy-related acute nonlymphocytic leukemia: evidence for a panmyelosis.

@article{Mckenna1981UltrastructuralCO,
  title={Ultrastructural characteristics of therapy-related acute nonlymphocytic leukemia: evidence for a panmyelosis.},
  author={Robert W Mckenna and Janet L. Parkin and Kathy Foucar and Richard D. Brunning},
  journal={Cancer},
  year={1981},
  volume={48 3},
  pages={725-37}
}
Leukemic cells from 13 patients with therapy-related acute nonlymphocytic leukemia (ANLL) were studied by electron microscopy. All of the patients had radiotherapy, and/or alkylating agent chemotherapy for other neoplastic disease 25 to 182 months prior to the diagnosis of ANLL. All cases manifested ultrastructural evidence of a panmyelopathy. All marrow cell lines exhibited nuclear--cytoplasmic asynchrony and abnormalities of cell size. Developing granulocytes exhibited decreased primary and… CONTINUE READING