Ultrastructural changes observed in rat ovaries following in utero and lactational exposure to low doses of a polybrominated flame retardant.

@article{Talsness2005UltrastructuralCO,
  title={Ultrastructural changes observed in rat ovaries following in utero and lactational exposure to low doses of a polybrominated flame retardant.},
  author={Chris E. Talsness and Mehdi Shakibaei and Sergio Noboru Kuriyama and Simone Wichert Grande and Anja Sterner-Kock and P. Stephen Schnitker and Cristina de Souza and Konstanze Grote and Ibrahim Chahoud},
  journal={Toxicology letters},
  year={2005},
  volume={157 3},
  pages={189-202}
}
Polybrominated diphenyl ethers (PBDEs), used as flame retardants in textiles, plastics and electrical appliances, have been shown to interfere with thyroid homeostasis. We evaluated the effects of environmentally relevant concentrations (low doses) of 2,2',4, 4',5-pentabromodiphenyl ether (PBDE-99) on the female reproductive system. A single dose of either 60 microg or 300 microg PBDE-99/kg body weight (BW) was administered on gestation day 6 to gravid Wistar rats. A reference control was… CONTINUE READING