Ultrastructural changes in beta-cells of pancreatic islets in alpha-amanitin-poisoned mice.

@article{Derenzini1978UltrastructuralCI,
  title={Ultrastructural changes in beta-cells of pancreatic islets in alpha-amanitin-poisoned mice.},
  author={Massimo Derenzini and Christine Margaret Betts and Corrado Busi and Luigi Fiume},
  journal={Virchows Archiv. B, Cell pathology},
  year={1978},
  volume={28 1},
  pages={13-20}
}
In mice poisoned by alpha-amanitin nuclear changes typical of this toxin were observed in beta-cells of pancreatic islets. The lesions became progressively more severe and at 48 h after toxin injection some cells were necrotic. The damage to these cells could have implications in the changes in glycogen metabolism which occur after alpha-aminitin poisoning. 
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