Ultrastructural and ultracytochemical characteristics of multinucleated cells after hydroxyapatite implantation into rat periodontal tissue.

@article{Kawaguchi1992UltrastructuralAU,
  title={Ultrastructural and ultracytochemical characteristics of multinucleated cells after hydroxyapatite implantation into rat periodontal tissue.},
  author={Hiroshi Kawaguchi and Tetsuji Ogawa and Masayori Shirakawa and Hiroshi Okamoto and Toskitaka Akisaka},
  journal={Journal of periodontal research},
  year={1992},
  volume={27 1},
  pages={48-54}
}
Multinucleated cells (MNCs) that appeared after hydroxyapatite (HAP) implantation into experimentally-produced bone defects in rat periodontal tissues were investigated both ultrastructurally and ultracytochemically. At day 5 after implantation, MNCs first appeared along the HAP surface. They had no features of typical osteoclasts such as ruffled border and clear zone. By d 14, these cells acquired features similar to osteoclasts, including ruffled border and clear zone. With the appearance of… CONTINUE READING

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