Ultrastructural and cytochemical study of hepatocytes and lymphocytes during experimental non-A, non-B infections in chimpanzees.

@article{Schaff1985UltrastructuralAC,
  title={Ultrastructural and cytochemical study of hepatocytes and lymphocytes during experimental non-A, non-B infections in chimpanzees.},
  author={Zsuzsa Schaff and Robert J. Gerety and Philip M. Grimley and Sten Iwarson and D. R. Jackson and Edward Tabor},
  journal={Journal of experimental pathology},
  year={1985},
  volume={2 1},
  pages={25-36}
}
A human agent of non-A, non-B hepatitis (Inoculum I) was transmitted to chimpanzees and alterations in liver and lymphocytes were studied by electron microscopy and by cytochemical techniques during the acute phase of the disease. Three types of cytoplasmic alterations, consisting of a membraneous and an amorphous part were observed in the hepatocytes. The density of the amorphous constituent decreased after treatment with pronase, but not after treatment with ribonuclease (RNase) or… CONTINUE READING