Ultrastructural and cytochemical studies of the fate of unsecreted collagen precursors after administration of colchicine to mice.


The administration of colchicine disrupts the normal organization of the Golgi complex and blocks the secretion of collagen precursors in periodontal ligament fibroblasts of the mouse. The fate of the unsecreted collagen precursors contained in Golgi-derived saccules and newly formed dense bodies was followed by electron microscopy. A progressive… (More)


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