Ultrastructural analysis of the progression of neurodegeneration in the septum following fimbria-fornix transection.

@article{Ginsberg1998UltrastructuralAO,
  title={Ultrastructural analysis of the progression of neurodegeneration in the septum following fimbria-fornix transection.},
  author={Stephen D Ginsberg and Lee J. Martin},
  journal={Neuroscience},
  year={1998},
  volume={86 4},
  pages={1259-72}
}
The fimbria-fornix transection paradigm has been used as a model of retrograde neurodegeneration within the medial septal nucleus and anterograde degeneration of axon terminals within the lateral septal nucleus. Because the maintenance and survival of neurons may depend on the integrity of both efferents and afferents, the ultrastructure of neurons in the medial septal nucleus and dorsolateral septal nucleus was analysed at three, seven, 14, 30 days, and six months following unilateral… CONTINUE READING