Ultrastructural analysis of human skin biopsy specimens from patients receiving recombinant human stem cell factor: subcutaneous injection of rhSCF induces dermal mast cell degranulation and granulocyte recruitment at the injection site.

Abstract

We performed an ultrastructural analysis of 10 skin biopsy specimens that had been obtained from three women who were undergoing daily subcutaneous dosing with recombinant methionyl-human stem cell factor (rhSCF) as part of a phase I clinical trial. The biopsy specimens were obtained at sites of subcutaneous administration of rhSCF, within approximately 1… (More)

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@article{Dvorak1998UltrastructuralAO, title={Ultrastructural analysis of human skin biopsy specimens from patients receiving recombinant human stem cell factor: subcutaneous injection of rhSCF induces dermal mast cell degranulation and granulocyte recruitment at the injection site.}, author={Ann M. Dvorak and John J. Costa and Rita A. Monahan-Earley and Patricia S. Fox and S J Galli}, journal={The Journal of allergy and clinical immunology}, year={1998}, volume={101 6 Pt 1}, pages={793-806} }