Ultrastructural analysis of human natural killer cell activation.

@article{Zarcone1987UltrastructuralAO,
  title={Ultrastructural analysis of human natural killer cell activation.},
  author={Daniela Zarcone and Edgar F. Prasthofer and Fabio Malavasi and Vito Pistoia and Albert F Lobuglio and Carlo Enrico Grossi},
  journal={Blood},
  year={1987},
  volume={69 6},
  pages={
          1725-36
        }
}
In this study we describe characteristic ultrastructural changes of CD3- large granular lymphocytes (LGL), ie, natural killer (NK) cells, following stimulation with recombinant (r) interleukin 2 (IL 2) or r-gamma interferon (r-gamma IFN) and after interaction with K562 target cells (TC) or Sepharose-bound anti-Fc gamma receptor (FcR) monoclonal antibody (MoAb). When compared to resting cells the cytolytic activity of r-IL 2- and r-gamma IFN-stimulated cells against K562 TC was enhanced. The r… CONTINUE READING

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