Ultrastructural analysis of hepatitis C virus particles.

@article{Catanese2013UltrastructuralAO,
  title={Ultrastructural analysis of hepatitis C virus particles.},
  author={Maria Teresa Catanese and Kunihiro Uryu and Martina Kopp and Thomas J Edwards and Linda Andrus and William E. Pine Kenneth H. Pollock Joseph E. Hightower Tho Rice and Mariena Silvestry and Richard J. Kuhn and Charles M. Rice},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 23},
  pages={9505-10}
}
Hepatitis C virus (HCV) is a major cause of chronic liver disease, with an estimated 170 million people infected worldwide. Low yields, poor stability, and inefficient binding to conventional EM grids have posed significant challenges to the purification and structural analysis of HCV. In this report, we generated an infectious HCV genome with an affinity tag fused to the E2 envelope glycoprotein. Using affinity grids, previously described to isolate proteins and macromolecular complexes for… CONTINUE READING
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