Ultrastructural analysis of experimentally induced invasion in the rat lung by tumor cells metastasizing lymphatically.

@article{Paku1986UltrastructuralAO,
  title={Ultrastructural analysis of experimentally induced invasion in the rat lung by tumor cells metastasizing lymphatically.},
  author={S{\'a}ndor Paku and Neidhard Paweletz and Eberhard Spiess and Paul Aulenbacher and H. O. Werling and M Knierim},
  journal={Anticancer research},
  year={1986},
  volume={6 5},
  pages={957-66}
}
The colonization of the lung by the rat tumor cells BSp73 ASML which have the ability to metastasize via the lymphatic system was studied at the ultrastructural level. Tumor cells arriving in the lung after i.v. injection become transiently embolized; within hours, however, they begin to extravasate from the blood capillaries. Swelling cellular protrusions open a limited area between endothelium and basal lamina through which tumor cells erupt. Tumor cells then form metastases in the… CONTINUE READING