Ultrastructural analysis of development of myocardium in calreticulin-deficient mice

Abstract

Calreticulin is a Ca2+ binding chaperone of the endoplasmic reticulum which influences gene expression and cell adhesion. The levels of both vinculin and N-cadherin are induced by calreticulin expression, which play important roles in cell adhesiveness. Cardiac development is strictly dependent upon the ability of cells to adhere to their substratum and to… (More)
DOI: 10.1186/1471-213X-6-54

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