Ultrastructural analysis of blood-brain barrier breakdown in the peri-infarct zone in young adult and aged mice.

@article{Nahirney2016UltrastructuralAO,
  title={Ultrastructural analysis of blood-brain barrier breakdown in the peri-infarct zone in young adult and aged mice.},
  author={Patrick C. Nahirney and Patrick Reeson and Craig E Brown},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2016},
  volume={36 2},
  pages={413-25}
}
Following ischemia, the blood-brain barrier is compromised in the peri-infarct zone leading to secondary injury and dysfunction that can limit recovery. Currently, it is uncertain what structural changes could account for blood-brain barrier permeability, particularly with aging. Here we examined the ultrastructure of early and delayed changes (3 versus 72 h) to the blood-brain barrier in young adult and aged mice (3-4 versus 18 months) subjected to photothrombotic stroke. At both time points… CONTINUE READING
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