Ultrastructural Bases for Metabolically Linked Mechanical Activity in Mitochondria

@article{Hackenbrock1966UltrastructuralBF,
  title={Ultrastructural Bases for Metabolically Linked Mechanical Activity in Mitochondria},
  author={Charles R. Hackenbrock},
  journal={The Journal of Cell Biology},
  year={1966},
  volume={37},
  pages={345 - 369}
}
By means of a new "quick-sampling" method, micropellets of mouse liver mitochondria were rapidly prepared for electron microscopy during the recording of steady state metabolism. Reversible ultrastructural changes were found to accompany change in metabolic steady states. The most dramatic reversible ultrastructural change occurs when ADP is added to systems in which only phosphate acceptor is deficient, i.e., during the State IV to State III transition as defined by Chance and Williams. After… CONTINUE READING
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