Ultrastructural Assessment of 2-(acridin-9-ylmethylene)-N-phenylhydrazinecarbothioamide activity on human breast adenocarcinoma cells.

Abstract

The aim of the present study was to investigate ultrastructural changes induced by (Z)-2-(acridin-9-ylmethylene)-N-phenylhydrazinecarbothioamide (APHCA) treatment on human breast adenocarcinoma cancer cells MCF-7, besides the evaluation of phosphatidylserine externalization and DNA fragmentation in treated cells. Cell viability analysis demonstrated… (More)
DOI: 10.1016/j.micron.2016.08.009

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@article{Almeida2016UltrastructuralAO, title={Ultrastructural Assessment of 2-(acridin-9-ylmethylene)-N-phenylhydrazinecarbothioamide activity on human breast adenocarcinoma cells.}, author={Sinara M{\^o}nica Vitalino de Almeida and L{\'u}cia Patr{\'i}cia Bezerra Gomes da Silva and Luiza Rayanna Amorim de Lima and Giovanna Barbarini Longato and Rafael Padilha and Luiz C. Alves and F. Brayner and Ana L{\'u}cia Tasca G{\'o}is Ruiz and Jo{\~a}o Ernesto de Carvalho and Eduardo Isidoro Carneiro Beltr{\~a}o and Maria do Carmo Alves de Lima and Luiz Bezerra de Carvalho J{\'u}nior}, journal={Micron}, year={2016}, volume={90}, pages={114-122} }