Ultrastructural Analysis in Preclinical Safety Evaluation

  title={Ultrastructural Analysis in Preclinical Safety Evaluation},
  author={Jane A. Fagerland and Henry G. Wall and Karamjeet Pandher and Bruce E Leroy and Gerard D. Gagn{\'e}},
  journal={Toxicologic Pathology},
  pages={391 - 402}
The first electron microscopic images of biological specimens were made in the 1940s, and the next 30 years comprised an era of descriptive ultrastructure during which transmission electron microscopy (TEM) was integral to an explosion in cellular and molecular biology. However, when questions could no longer be answered by ultrastructural information alone, the use of TEM in biological research declined. Innovative molecular techniques and newer imaging technologies such as confocal… 

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