Ultrastructural Analysis in Preclinical Safety Evaluation

@article{Fagerland2012UltrastructuralAI,
  title={Ultrastructural Analysis in Preclinical Safety Evaluation},
  author={Jane A. Fagerland and H. Wall and K. Pandher and B. Leroy and G. Gagn{\'e}},
  journal={Toxicologic Pathology},
  year={2012},
  volume={40},
  pages={391 - 402}
}
  • Jane A. Fagerland, H. Wall, +2 authors G. Gagné
  • Published 2012
  • Medicine
  • Toxicologic Pathology
  • The first electron microscopic images of biological specimens were made in the 1940s, and the next 30 years comprised an era of descriptive ultrastructure during which transmission electron microscopy (TEM) was integral to an explosion in cellular and molecular biology. However, when questions could no longer be answered by ultrastructural information alone, the use of TEM in biological research declined. Innovative molecular techniques and newer imaging technologies such as confocal… CONTINUE READING
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    References

    SHOWING 1-10 OF 29 REFERENCES
    Morphogenesis of Postmortem Hepatocyte Vacuolation and Liver Weight Increases in Sprague-Dawley Rats
    • 32
    Drug-induced phospholipidosis: issues and future directions
    • 186
    An ultrastructural study of the mechanisms of proteinuria in aminonucleoside nephrosis.
    • 284
    Asymptomatic Macrothrombocytopenia in a Young Pure-Bred Beagle Dog
    • 2
    Lysosomes and oxidative stress in aging and apoptosis.
    • 224
    LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis
    • 436
    • PDF
    Mutation in beta1-tubulin correlates with macrothrombocytopenia in Cavalier King Charles Spaniels.
    • 59
    Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection.
    • 142
    • PDF
    Imaging mass spectrometry: fundamentals and applications to drug discovery.
    • 156