Ultrastrong trapping of VEGF by graphene oxide: Anti-angiogenesis application.

@article{Lai2016UltrastrongTO,
  title={Ultrastrong trapping of VEGF by graphene oxide: Anti-angiogenesis application.},
  author={Pei-Xin Lai and Chung-Wein Chen and Shih-Chun Wei and Tzu-yu Lin and Hong-Jyuan Jian and Irving Po-Jung Lai and Ju-Yi Mao and Pang-Hung Hsu and Han-Jia Lin and Wen-Shyong Tzou and Shiow-Yi Chen and Scott G Harroun and Jui-Yang Lai and Chih-Ching Huang},
  journal={Biomaterials},
  year={2016},
  volume={109},
  pages={
          12-22
        }
}
Angiogenesis is the process of formation of new blood vessels, which is essential to human biology, and also plays a crucial role in several pathologies such as tumor growth and metastasis, exudative age-related macular degeneration, and ischemia. Vascular endothelial growth factor (VEGF), in particular, VEGF-A165 is the most important pro-angiogenic factor for angiogenesis. Thus, blocking the interaction between VEGFs and their receptors is considered an effective anti-angiogenic strategy. We… CONTINUE READING

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