Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers.

  title={Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers.},
  author={Farzin Haque and D. -F. Shu and Y. N. Shu and L. S. Shlyakhtenko and Piotr G. Rychahou and Bernard Mark Evers and Peixuan Guo},
  journal={Nano today},
  volume={7 4},
One of the advantages of nanotechnology is the feasibility to construct therapeutic particles carrying multiple therapeutics with defined structure and stoichiometry. The field of RNA nanotechnology is emerging. However, controlled assembly of stable RNA nanoparticles with multiple functionalities which retain their original role is challenging due to refolding after fusion. Herein, we report the construction of thermodynamically stable X-shaped RNA nanoparticles to carry four therapeutic RNA… CONTINUE READING
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