Ultrasound triggered drug release from 10-hydroxycamptothecin-loaded phospholipid microbubbles for targeted tumor therapy in mice.

@article{Li2012UltrasoundTD,
  title={Ultrasound triggered drug release from 10-hydroxycamptothecin-loaded phospholipid microbubbles for targeted tumor therapy in mice.},
  author={Pan Li and Yuanyi Zheng and Haitao Ran and Jinxiang Tan and Yanjun Lin and Qunxia Zhang and JianLi Ren and Zhigang Wang},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={162 2},
  pages={349-54}
}
Ultrasound targeted microbubble destruction (UTMD) was one of the most promising strategies to enhance drug delivery in cancer therapy. Microbubbles (MBs) serve as a vehicle to carry anti-tumor drugs and locally release them when exposed to therapeutic ultrasound, resulting in drug accumulation in tumor tissues and enhanced anti-tumor effect. However the ultrasound triggered drug delivery system has been seriously limited due to the poor loading capacity of MBs. Here we present a new strategy… CONTINUE READING
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