Ultrasound stimulates cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, phosphatidylinositol 3-kinase, and Akt pathway in osteoblasts.

@article{Tang2006UltrasoundSC,
  title={Ultrasound stimulates cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, phosphatidylinositol 3-kinase, and Akt pathway in osteoblasts.},
  author={Chih-Hsin Tang and Rong-Sen Yang and Tsang-Hai Huang and Dah-Yuu Lu and Woei-Jer Chuang and Tur-Fu Huang and Wen-mei Fu},
  journal={Molecular pharmacology},
  year={2006},
  volume={69 6},
  pages={
          2047-57
        }
}
It has been shown that ultrasound (US) stimulation accelerates fracture healing in animal models and in clinical studies. Here we found that US stimulation transiently increased the surface expression of alpha2, alpha5, beta1, and beta3 integrins in cultured osteoblasts, as shown by flow cytometric analysis and immunofluorescence staining. US stimulation increased prostaglandin E(2) formation and the protein and mRNA levels of cyclooxygenase-2 (COX-2). At the mechanistic level, anti-integrin… CONTINUE READING

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