Ultrasound-promoted greener synthesis of 2,4,5-trisubstituted imidazoles catalyzed by Zr(acac)4 under ambient conditions.

A simple, efficient and green procedure has been developed for the synthesis of 2,4,5-trisubstituted imidazoles catalyzed by zirconium (IV) acetylacetonate using ultrasonic irradiation. The present methodology offers several advantages such as excellent yields, simple procedure, short reaction times and milder conditions.