Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions.

@article{Rapoport2011UltrasoundmediatedTI,
  title={Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions.},
  author={Natalya Y Rapoport and K Nam and Roohi Gupta and Zhongao Gao and Praveena Mohan and A. Payne and N. B. Todd and Xin Liu and Taeho Kim and Jill Shea and Courtney L. Scaife and Dennis L. Parker and Eun-Kee Jeong and Anne M. Kennedy},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2011},
  volume={153 1},
  pages={4-15}
}
Perfluorocarbon nanoemulsions can deliver lipophilic therapeutic agents to solid tumors and simultaneously provide for monitoring nanocarrier biodistribution via ultrasonography and/or (19)F MRI. In the first generation of block copolymer stabilized perfluorocarbon nanoemulsions, perfluoropentane (PFP) was used as the droplet forming compound. Although manifesting excellent therapeutic and ultrasound imaging properties, PFP nanoemulsions were unstable at storage, difficult to handle, and… CONTINUE READING

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