Ultrasound-mediated disruption of cell membranes. I. Quantification of molecular uptake and cell viability.

@article{Guzmn2001UltrasoundmediatedDO,
  title={Ultrasound-mediated disruption of cell membranes. I. Quantification of molecular uptake and cell viability.},
  author={H{\'e}ctor R. Guzm{\'a}n and Daniel X. Nguyen and Sohail Khan and Mark R. Prausnitz},
  journal={The Journal of the Acoustical Society of America},
  year={2001},
  volume={110 1},
  pages={588-96}
}
Ultrasound-mediated drug delivery is a nonchemical, nonviral, and noninvasive method for targeted transport of drugs and genes into cells. Molecules can be delivered into cells when ultrasound disrupts the cell membrane by a mechanism believed to involve cavitation. This study examined molecular uptake and cell viability in cell suspensions (DU145 prostate cancer and aortic smooth muscle cells) exposed to varying peak negative acoustic pressures (0.6-3.0 MPa), exposure times (120-2000 ms), and… CONTINUE READING

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