Ultrasound-mediated disruption of cell membranes

  title={Ultrasound-mediated disruption of cell membranes},
  author={H{\'e}ctor R. Guzm{\'a}n and Daniel X. Nguyen and Sohail Khan and Mark R. Prausnitza},
Ultrasound-mediated drug delivery is a nonchemical, nonviral, and noninvasive method for targeted transport of drugs and genes into cells. Molecules can be delivered into cells when ultrasound disrupts the cell membrane by a mechanism believed to involve cavitation. This study examined molecular uptake and cell viability in cell suspensions ~DU145 prostate cancer and aortic smooth muscle cells ! exposed to varying peak negative acoustic pressures ~0.6–3.0 MPa!, exposure times ~120–2000 ms… CONTINUE READING


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