Ultrasound-mediated destruction of LHRHa-targeted and paclitaxel-loaded lipid microbubbles induces proliferation inhibition and apoptosis in ovarian cancer cells.

@article{Liu2014UltrasoundmediatedDO,
  title={Ultrasound-mediated destruction of LHRHa-targeted and paclitaxel-loaded lipid microbubbles induces proliferation inhibition and apoptosis in ovarian cancer cells.},
  author={Hongxia Liu and Shufang Chang and Jiangchuan Sun and Shenyin Zhu and Caixiu Pu and Yi Zhu and Zhigang Wang and Ronald X Xu},
  journal={Molecular pharmaceutics},
  year={2014},
  volume={11 1},
  pages={40-8}
}
Although paclitaxel (PTX) is used with platinum as the first line chemotherapy regimen for ovarian cancer, its clinical efficacy is often limited by severe adverse effects. Ultrasound-targeted microbubble destruction (UTMD) technique holds a great promise in minimizing the side effects and maximizing the therapeutic efficacy. However, the technique… CONTINUE READING