Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system.

@article{Aryal2014UltrasoundmediatedBB,
  title={Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system.},
  author={Muna Aryal and Costas D. Arvanitis and Phillip M Alexander and Nathan J. McDannold},
  journal={Advanced drug delivery reviews},
  year={2014},
  volume={72},
  pages={94-109}
}
The physiology of the vasculature in the central nervous system (CNS), which includes the blood-brain barrier (BBB) and other factors, complicates the delivery of most drugs to the brain. Different methods have been used to bypass the BBB, but they have limitations such as being invasive, non-targeted or requiring the formulation of new drugs. Focused ultrasound (FUS), when combined with circulating microbubbles, is a noninvasive method to locally and transiently disrupt the BBB at discrete… CONTINUE READING
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