Ultrasound ionization of biomolecules.

  title={Ultrasound ionization of biomolecules.},
  author={Chen-I Wu and Y Wang and Nelson G. Chen and Chung-Yi Wu and Chung-Hsuan Chen},
  journal={Rapid communications in mass spectrometry : RCM},
  volume={24 17},
To date, mass spectrometric analysis of biomolecules has been primarily performed with either matrix-assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI). In this work, ultrasound produced by a simple piezoelectric device is shown as an alternative method for soft ionization of biomolecules. Precursor ions of proteins, saccharides and fatty acids showed little fragmentation. Cavitation is considered as a primary mechanism for the ionization of biomolecules.